Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Though motor neurons (MNs) selectively degenerate in amyotrophic lateral sclerosis (ALS), other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected microglia would contribute to...

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Detalles Bibliográficos
Autores principales: Spiller, Krista J., Restrepo, Clark R., Khan, Tahiyana, Dominique, Myrna A., Fang, Terry C., Canter, Rebecca G., Roberts, Christopher, Miller, Kelly R., Ransohoff, Richard M., Trojanowski, John Q., Lee, Virginia M-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857237/
https://www.ncbi.nlm.nih.gov/pubmed/29463850
http://dx.doi.org/10.1038/s41593-018-0083-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857237/
https://www.ncbi.nlm.nih.gov/pubmed/29463850
http://dx.doi.org/10.1038/s41593-018-0083-7

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