Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

BACKGROUND: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes different...

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Detalles Bibliográficos
Autores principales: Martin, Nellie A., Molnar, Viktor, Szilagyi, Gabor T., Elkjaer, Maria L., Nawrocki, Arkadiusz, Okarmus, Justyna, Wlodarczyk, Agnieszka, Thygesen, Eva K., Palkovits, Miklos, Gallyas, Ferenc, Larsen, Martin R., Lassmann, Hans, Benedikz, Eirikur, Owens, Trevor, Svenningsen, Asa F., Illes, Zsolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857529/
https://www.ncbi.nlm.nih.gov/pubmed/29593734
http://dx.doi.org/10.3389/fimmu.2018.00490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857529/
https://www.ncbi.nlm.nih.gov/pubmed/29593734
http://dx.doi.org/10.3389/fimmu.2018.00490

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