Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding

Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there are choices aplenty. However, the functions of these...

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Detalles Bibliográficos
Autores principales: Ling, Wei-Li, Lua, Wai-Heng, Poh, Jun-Jie, Yeo, Joshua Yi, Lane, David Philip, Gan, Samuel Ken-En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857972/
https://www.ncbi.nlm.nih.gov/pubmed/29593727
http://dx.doi.org/10.3389/fimmu.2018.00469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857972/
https://www.ncbi.nlm.nih.gov/pubmed/29593727
http://dx.doi.org/10.3389/fimmu.2018.00469

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