A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation

Site-specific alkylation of complex biomolecules is critical for late-stage product diversification as well as post-synthetic labeling and manipulation of proteins and nucleic acids. Promiscuous methyltransferases in combination with analogs of S-adenosyl-l-methionine (AdoMet) can functionalize all...

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Detalles Bibliográficos
Autores principales: Muttach, F., Muthmann, N., Reichert, D., Anhäuser, L., Rentmeister, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858020/
https://www.ncbi.nlm.nih.gov/pubmed/29619168
http://dx.doi.org/10.1039/c7sc03631k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858020/
https://www.ncbi.nlm.nih.gov/pubmed/29619168
http://dx.doi.org/10.1039/c7sc03631k

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