3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

Rationale: Cardenolides have potential as anticancer drugs. 3′-epi-12β-hydroxyfroside (HyFS) is a new cardenolide structure isolated by our research group, but its molecular mechanisms remain poorly understood. This study investigates the relationship between its antitumor activities and autophagy i...

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Detalles Bibliográficos
Autores principales: Sun, Yan, Huang, Yong-Hao, Huang, Feng-Ying, Mei, Wen-Li, Liu, Quan, Wang, Cai-Chun, Lin, Ying-Ying, Huang, Canhua, Li, Yue-Nan, Dai, Hao-Fu, Tan, Guang-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858516/
https://www.ncbi.nlm.nih.gov/pubmed/29556372
http://dx.doi.org/10.7150/thno.23304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858516/
https://www.ncbi.nlm.nih.gov/pubmed/29556372
http://dx.doi.org/10.7150/thno.23304

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