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A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics
The development of therapeutic monoclonal antibodies through mouse immunization often originates drug candidates that are not cross-reactive to the mouse ortholog. In such cases, and particularly in oncology, drug efficacy studies are performed on human tumor xenografts or with “surrogate” anti-mous...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858835/ https://www.ncbi.nlm.nih.gov/pubmed/29554149 http://dx.doi.org/10.1371/journal.pone.0194688 |