Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy

Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors, adaptors, cullin scaffolds, and RING-box proteins. CRLs are responsible for ubiquitination of ~20% of cellular prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, Sang-Min, Redon, Christophe E., Aladjem, Mirit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859106/
https://www.ncbi.nlm.nih.gov/pubmed/29594129
http://dx.doi.org/10.3389/fmolb.2018.00019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859106/
https://www.ncbi.nlm.nih.gov/pubmed/29594129
http://dx.doi.org/10.3389/fmolb.2018.00019

Ejemplares similares