Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs

Familial Hypertrophic Cardiomyopathy (HCM) is the most common inherited cardiac disease. About 30% of the patients are heterozygous for mutations in the MYH7 gene encoding the ß-myosin heavy chain (MyHC). Hallmarks of HCM are cardiomyocyte disarray and hypertrophy of the left ventricle, the symptoms...

Descripción completa

Detalles Bibliográficos
Autores principales: Montag, J., Petersen, B., Flögel, A. K., Becker, E., Lucas-Hahn, A., Cost, G. J., Mühlfeld, C., Kraft, T., Niemann, H., Brenner, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859159/
https://www.ncbi.nlm.nih.gov/pubmed/29555974
http://dx.doi.org/10.1038/s41598-018-22936-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859159/
https://www.ncbi.nlm.nih.gov/pubmed/29555974
http://dx.doi.org/10.1038/s41598-018-22936-z

Ejemplares similares