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Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs
Familial Hypertrophic Cardiomyopathy (HCM) is the most common inherited cardiac disease. About 30% of the patients are heterozygous for mutations in the MYH7 gene encoding the ß-myosin heavy chain (MyHC). Hallmarks of HCM are cardiomyocyte disarray and hypertrophy of the left ventricle, the symptoms...
Autores principales: | Montag, J., Petersen, B., Flögel, A. K., Becker, E., Lucas-Hahn, A., Cost, G. J., Mühlfeld, C., Kraft, T., Niemann, H., Brenner, B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859159/ https://www.ncbi.nlm.nih.gov/pubmed/29555974 http://dx.doi.org/10.1038/s41598-018-22936-z |
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