Frataxin overexpression in Müller cells protects retinal ganglion cells in a mouse model of ischemia/reperfusion injury in vivo

Müller cells are critical for retinal function and neuronal survival but can become detrimental in response to retinal ischemia and increased oxidative stress. Elevated oxidative stress increases expression of the mitochondrial enzyme frataxin in the retina, and its overexpression is neuroprotective...

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Detalles Bibliográficos
Autores principales: Schultz, Rowena, Krug, Melanie, Precht, Michel, Wohl, Stefanie G., Witte, Otto W., Schmeer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859167/
https://www.ncbi.nlm.nih.gov/pubmed/29555919
http://dx.doi.org/10.1038/s41598-018-22887-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859167/
https://www.ncbi.nlm.nih.gov/pubmed/29555919
http://dx.doi.org/10.1038/s41598-018-22887-5

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