PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation

HDAC3 is involved in deacetylation of histone and non-histone proteins, having a key role in the regulation of gene transcription and also in the process of tumorgenesis. However, how HDAC3 is regulated in cancer remains largely unclear. Here, we showed that PIWIL2 can interact with HDAC3, leading t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yingying, Zheng, Xulei, Tan, Hao, Lu, Yilu, Tao, Dachang, Liu, Yunqiang, Ma, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859188/
https://www.ncbi.nlm.nih.gov/pubmed/29555935
http://dx.doi.org/10.1038/s41419-018-0462-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859188/
https://www.ncbi.nlm.nih.gov/pubmed/29555935
http://dx.doi.org/10.1038/s41419-018-0462-8

Ejemplares similares