Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of deleterious mutations. Here we use a Porcupine inhibitor to reduce Wnt secreti...

Descripción completa

Detalles Bibliográficos
Autores principales: Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., Zeiger, L. B., McLaughlin, M. E., Morrissey, E., Winton, D. J., Snippert, H. J., van Rheenen, J., Sansom, O. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859272/
https://www.ncbi.nlm.nih.gov/pubmed/29556067
http://dx.doi.org/10.1038/s41467-018-03426-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859272/
https://www.ncbi.nlm.nih.gov/pubmed/29556067
http://dx.doi.org/10.1038/s41467-018-03426-2

Ejemplares similares