An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evolutionary sequence analysis to identify co-evolvin...

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Detalles Bibliográficos
Autores principales: Rosensweig, Clark, Reynolds, Kimberly A., Gao, Peng, Laothamatas, Isara, Shan, Yongli, Ranganathan, Rama, Takahashi, Joseph S., Green, Carla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859286/
https://www.ncbi.nlm.nih.gov/pubmed/29556064
http://dx.doi.org/10.1038/s41467-018-03503-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859286/
https://www.ncbi.nlm.nih.gov/pubmed/29556064
http://dx.doi.org/10.1038/s41467-018-03503-6

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