Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly. Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in senile plaques in brain of AD patients. To understand Zn-chelated Aβ (ZnAβ) species, here we systematically characterized...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Ming-Che, Yu, Wan-Cheng, Shih, Yao-Hsiang, Chen, Chun-Yu, Guo, Zhong-Hong, Huang, Shing-Jong, Chan, Jerry C. C., Chen, Yun-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859292/
https://www.ncbi.nlm.nih.gov/pubmed/29555950
http://dx.doi.org/10.1038/s41598-018-23122-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859292/
https://www.ncbi.nlm.nih.gov/pubmed/29555950
http://dx.doi.org/10.1038/s41598-018-23122-x

Ejemplares similares