Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin

The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes, obesity, cancer, aging, cardiovascular disease and neurodegeneration. Despite the importa...

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Detalles Bibliográficos
Autores principales: Sengupta, Soham, Nechushtai, Rachel, Jennings, Patricia A., Onuchic, Jose’ N., Padilla, Pamela A., Azad, Rajeev K., Mittler, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859297/
https://www.ncbi.nlm.nih.gov/pubmed/29556009
http://dx.doi.org/10.1038/s41598-018-23305-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859297/
https://www.ncbi.nlm.nih.gov/pubmed/29556009
http://dx.doi.org/10.1038/s41598-018-23305-6

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