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Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin
The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes, obesity, cancer, aging, cardiovascular disease and neurodegeneration. Despite the importa...
Autores principales: | Sengupta, Soham, Nechushtai, Rachel, Jennings, Patricia A., Onuchic, Jose’ N., Padilla, Pamela A., Azad, Rajeev K., Mittler, Ron |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859297/ https://www.ncbi.nlm.nih.gov/pubmed/29556009 http://dx.doi.org/10.1038/s41598-018-23305-6 |
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