A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery

The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that restrict many viruses, including HIV-1. SAMHD1 is another restriction factor blocking replication of HIV-1 and other viruses. Some lentiviruses evolved Vpx/Vpr proteins to degrade SAMHD1. However, this viral a...

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Detalles Bibliográficos
Autores principales: Roesch, Ferdinand, OhAinle, Molly, Emerman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859395/
https://www.ncbi.nlm.nih.gov/pubmed/29554922
http://dx.doi.org/10.1186/s12977-018-0409-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859395/
https://www.ncbi.nlm.nih.gov/pubmed/29554922
http://dx.doi.org/10.1186/s12977-018-0409-2

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