Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

BACKGROUND: Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, the underlying molecular mechanisms have not been clearly elucidated. METHODS: The anti-myeloma eff...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Xu, Wenbin, Yan, Zixun, Zhao, Weili, Mi, Jianqing, Li, Junmin, Yan, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859411/
https://www.ncbi.nlm.nih.gov/pubmed/29554968
http://dx.doi.org/10.1186/s13046-018-0731-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859411/
https://www.ncbi.nlm.nih.gov/pubmed/29554968
http://dx.doi.org/10.1186/s13046-018-0731-5

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