Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing

PURPOSE: This study addresses the effect of freezing and thawing on a therapeutic monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle formation, crystallization behaviour, morphology changes and cryo-concentration effects were studied after varying the freezing and...

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Detalles Bibliográficos
Autores principales: Hauptmann, Astrid, Podgoršek, Katja, Kuzman, Drago, Srčič, Stanko, Hoelzl, Georg, Loerting, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859698/
https://www.ncbi.nlm.nih.gov/pubmed/29556730
http://dx.doi.org/10.1007/s11095-018-2378-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859698/
https://www.ncbi.nlm.nih.gov/pubmed/29556730
http://dx.doi.org/10.1007/s11095-018-2378-5

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