Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a

Both Parkin and UBE3A are E3 ubiquitin ligases whose mutations result in severe brain dysfunction. Several of their substrates have been identified using cell culture models in combination with proteasome inhibitors, but not in more physiological settings. We recently developed the (bio)Ub strategy...

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Detalles Bibliográficos
Autores principales: Martinez, Aitor, Ramirez, Juanma, Osinalde, Nerea, Arizmendi, Jesus M., Mayor, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859835/
https://www.ncbi.nlm.nih.gov/pubmed/29693004
http://dx.doi.org/10.1155/2018/3180413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859835/
https://www.ncbi.nlm.nih.gov/pubmed/29693004
http://dx.doi.org/10.1155/2018/3180413

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