Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates

[Image: see text] Cyclic ribosomally derived peptides possess diverse bioactivities and are currently of major interest in drug development. However, it can be chemically challenging to synthesize these molecules, hindering the diversification and testing of cyclic peptide leads. Enzymes used in vit...

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Detalles Bibliográficos
Autores principales: Ludewig, Hannes, Czekster, Clarissa M., Oueis, Emilia, Munday, Elizabeth S., Arshad, Mohammed, Synowsky, Silvia A., Bent, Andrew F., Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859912/
https://www.ncbi.nlm.nih.gov/pubmed/29377663
http://dx.doi.org/10.1021/acschembio.8b00050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859912/
https://www.ncbi.nlm.nih.gov/pubmed/29377663
http://dx.doi.org/10.1021/acschembio.8b00050

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