Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers

The discoidin domain receptor 1 (DDR1) is overexpressed in breast carcinoma cells. Low DDR1 expression is associated with worse relapse-free survival, reflecting its controversial role in cancer progression. We detected DDR1 on luminal cells but not on myoepithelial cells of DDR1(+/+) mice. We found...

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Detalles Bibliográficos
Autores principales: Takai, Ken, Drain, Allison P., Lawson, Devon A., Littlepage, Laurie E., Karpuj, Marcela, Kessenbrock, Kai, Le, Annie, Inoue, Kenichi, Weaver, Valerie M., Werb, Zena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859966/
https://www.ncbi.nlm.nih.gov/pubmed/29483153
http://dx.doi.org/10.1101/gad.301366.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859966/
https://www.ncbi.nlm.nih.gov/pubmed/29483153
http://dx.doi.org/10.1101/gad.301366.117

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