Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population

Variants in HNF1A encoding hepatocyte nuclear factor 1α (HNF-1A) are associated with maturity-onset diabetes of the young form 3 (MODY 3) and type 2 diabetes. We investigated whether functional classification of HNF1A rare coding variants can inform models of diabetes risk prediction in the general...

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Detalles Bibliográficos
Autores principales: Najmi, Laeya Abdoli, Aukrust, Ingvild, Flannick, Jason, Molnes, Janne, Burtt, Noel, Molven, Anders, Groop, Leif, Altshuler, David, Johansson, Stefan, Bjørkhaug, Lise, Njølstad, Pål Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860263/
https://www.ncbi.nlm.nih.gov/pubmed/27899486
http://dx.doi.org/10.2337/db16-0460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860263/
https://www.ncbi.nlm.nih.gov/pubmed/27899486
http://dx.doi.org/10.2337/db16-0460

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