Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance

Obesity and type 2 diabetes are associated with impaired mitochondrial function in adipose tissue. To study the effects of primary deficiency of mitochondrial energy metabolism in fat, we generated mice with adipose-specific deficiency of fumarate hydratase (FH), an integral Krebs cycle enzyme (AFHK...

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Detalles Bibliográficos
Autores principales: Yang, Hao, Wu, Jiang W., Wang, Shu P., Severi, Ilenia, Sartini, Loris, Frizzell, Norma, Cinti, Saverio, Yang, Gongshe, Mitchell, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860441/
https://www.ncbi.nlm.nih.gov/pubmed/27554470
http://dx.doi.org/10.2337/db16-0136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860441/
https://www.ncbi.nlm.nih.gov/pubmed/27554470
http://dx.doi.org/10.2337/db16-0136

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