PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT

Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key molecule of glucose metabolism in cytoplasm, has been found in various tumors. Emerging evidence has suggested that PFKFB3 is also located in the nucleus and apparent in regulatory functions other than glycolysis...

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Detalles Bibliográficos
Autores principales: Shi, Wen-Kai, Zhu, Xiao-Dong, Wang, Cheng-Hao, Zhang, Yuan-Yuan, Cai, Hao, Li, Xiao-Long, Cao, Man-Qing, Zhang, Shi-Zhe, Li, Kang-Shuai, Sun, Hui-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861039/
https://www.ncbi.nlm.nih.gov/pubmed/29559632
http://dx.doi.org/10.1038/s41419-018-0435-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861039/
https://www.ncbi.nlm.nih.gov/pubmed/29559632
http://dx.doi.org/10.1038/s41419-018-0435-y

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