The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts

Small cell lung cancer (SCLC) is a highly aggressive, predominantly cigarette smoke-induced tumour with poor prognosis. The glucocorticoid receptor (GR), a SCLC tumour suppressor gene, is typically reduced in SCLC. We now show that SCLC cells express high levels of DNA methyltransferase 1 (DNMT1) wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, Kerryn M., Wheeler, Roxanne, Singh, Nimisha, Vosloo, Dalene, Ray, David W., Sommer, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861118/
https://www.ncbi.nlm.nih.gov/pubmed/29559689
http://dx.doi.org/10.1038/s41598-018-23309-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861118/
https://www.ncbi.nlm.nih.gov/pubmed/29559689
http://dx.doi.org/10.1038/s41598-018-23309-2

Ejemplares similares