High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells

High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin). We demonstrated that HMGN1 not only directly stimulated...

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Detalles Bibliográficos
Autores principales: Arts, Rob J. W., Huang, Po-Kai, Yang, De, Joosten, Leo A. B., van der Meer, Jos W. M., Oppenheim, Joost J., Netea, Mihai G., Cheng, Shih-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861144/
https://www.ncbi.nlm.nih.gov/pubmed/29593748
http://dx.doi.org/10.3389/fimmu.2018.00526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861144/
https://www.ncbi.nlm.nih.gov/pubmed/29593748
http://dx.doi.org/10.3389/fimmu.2018.00526

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