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Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?

Several lines of evidence place alpha-synuclein (aSyn) at the center of Parkinson's disease (PD) etiology, but it is still unclear why overexpression or mutated forms of this protein affect some neuronal populations more than others. Susceptible neuronal populations in PD, dopaminergic neurons...

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Detalles Bibliográficos
Autores principales: Post, Michael R., Lieberman, Ori J., Mosharov, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861202/
https://www.ncbi.nlm.nih.gov/pubmed/29593491
http://dx.doi.org/10.3389/fnins.2018.00161