Cargando…

The Cytochrome P450-Mediated Metabolism Alternation of Four Effective Lignans From Schisandra chinensis in Carbon Tetrachloride-Intoxicated Rats and Patients With Advanced Hepatocellular Carcinoma

It is highly valuable to study the pharmacokinetics of herbal components under the pathological condition of liver dysfunction for safe and rational use of herbal medicines. In this study, the pharmacokinetic profiles of four effective lignans from Schisandra chinensis (SC), schisandrin, schisanther...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Rongrong, Xiao, Zhiyong, Zhang, Xiaorui, Liu, Feng, Zhou, Wenxia, Zhang, Yongxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861220/ https://www.ncbi.nlm.nih.gov/pubmed/29593545 http://dx.doi.org/10.3389/fphar.2018.00229

Ejemplares similares

A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities
por: Zhang, Feng, et al.
Publicado: (2022)

Schizandrol A: a lignan from Schisandra chinensis
por: Zhao, Liang, et al.
Publicado: (2008)

Targeted Lignan Profiling and Anti-Inflammatory Properties of Schisandra rubriflora and Schisandra chinensis Extracts
por: Szopa, Agnieszka, et al.
Publicado: (2018)

Dibenzocyclooctadiene Lignans in Plant Parts and Fermented Beverages of Schisandra chinensis
por: Park, Woo Sung, et al.
Publicado: (2021)

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models
por: Šmejkal, Karel, et al.
Publicado: (2010)

Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice
por: Sun, Jing-Hui, et al.
Publicado: (2017)

Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes
por: Seo, Hyung-Ju, et al.
Publicado: (2021)

Simultaneous determination of eleven characteristic lignans in Schisandra chinensis by high-performance liquid chromatography
por: Hu, Junyang, et al.
Publicado: (2013)

Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans on aging rats induced by d-galactose
por: Sun, Jinghui, et al.
Publicado: (2018)

A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
por: Li, Fenghua, et al.
Publicado: (2017)

Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ (1–42)-Induced Memory Impairment in Mice
por: Hu, Di, et al.
Publicado: (2012)

Improved production of dibenzocyclooctadiene lignans in the elicited microshoot cultures of Schisandra chinensis (Chinese magnolia vine)
por: Szopa, Agnieszka, et al.
Publicado: (2017)

Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship
por: Deng, Lu-Lu, et al.
Publicado: (2021)

Accumulation of dibenzocyclooctadiene lignans in agar cultures and in stationary and agitated liquid cultures of Schisandra chinensis (Turcz.) Baill
por: Szopa, Agnieszka, et al.
Publicado: (2015)

Long-read transcriptome sequencing provides insight into lignan biosynthesis during fruit development in Schisandra chinensis
por: Hong, Chang Pyo, et al.
Publicado: (2022)

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis
por: Shang, Shan-Zhai, et al.
Publicado: (2013)

Identification, Molecular Cloning, and Functional Characterization of a Coniferyl Alcohol Acyltransferase Involved in the Biosynthesis of Dibenzocyclooctadiene Lignans in Schisandra chinensis
por: Qiang, Ting-Yan, et al.
Publicado: (2022)

Study on the Hepatoprotection of Schisandra chinensis Caulis Polysaccharides in Nonalcoholic Fatty Liver Disease in Rats Based on Metabolomics
por: Feng, Yanbo, et al.
Publicado: (2021)

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
por: Zhang, Shui-Mei, et al.
Publicado: (2022)

Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae
por: Zhao, Li-Chun, et al.
Publicado: (2012)

Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity
por: Du, Jie, et al.
Publicado: (2022)

Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta
por: Chen, Min, et al.
Publicado: (2013)

Stimulation of Lignan Production in Schisandra rubriflora In Vitro Cultures by Elicitation
por: Szopa, Agnieszka, et al.
Publicado: (2022)

Schisandra Lignan Extract Protects against Carbon Tetrachloride-Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF-κB and JNK Signaling Pathways
por: Chen, Qingshan, et al.
Publicado: (2017)

Schisandra chinensis Peptidoglycan-Assisted Transmembrane Transport of Lignans Uniquely Altered the Pharmacokinetic and Pharmacodynamic Mechanisms in Human HepG2 Cell Model
por: Chyau, Charng-Cherng, et al.
Publicado: (2014)

Total Lignans of Schisandra chinensis Ameliorates Aβ(1-42)-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells
por: Zhao, Xu, et al.
Publicado: (2016)

Effects of diarylbutane lignans from Schisandra chinensis fruit on SARS-CoV-2 3CL(pro) and PL(pro) and their in vitro anti-inflammatory properties
por: Li, Bin, et al.
Publicado: (2023)

Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans
por: Koyama, Tomotsugu, et al.
Publicado: (2022)

Neglschisandrins C-D: Two New Dibenzocyclooctadiene Lignans from Schisandra neglecta
por: Chen, Min, et al.
Publicado: (2008)

Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines
por: Xue, Lijuan, et al.
Publicado: (2023)

Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis
por: Liao, Weifang, et al.
Publicado: (2017)

Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice
por: Zeng, Ju, et al.
Publicado: (2020)

Schisandra Chinensis Lignans Suppresses the Production of Inflammatory Mediators Regulated by NF-κB, AP-1, and IRF3 in Lipopolysaccharide-Stimulated RAW264.7 Cells
por: Luo, Gan, et al.
Publicado: (2018)

Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents
por: Kopustinskiene, Dalia M., et al.
Publicado: (2021)

De novo transcriptome assembly of Schisandra chinensis Turcz. (Baill.)
por: qing-tian, Zhang, et al.
Publicado: (2016)

Neglschisandrins A-B: Two New Dibenzocyclooctene Lignans from Schisandra neglecta
por: Chen, Min, et al.
Publicado: (2008)

Pharmacokinetic Compatibility of Ginsenosides and Schisandra Lignans in Shengmai-san: From the Perspective of P-Glycoprotein
por: Liang, Yan, et al.
Publicado: (2014)

Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ(1-42)-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells
por: Yang, Bing-You, et al.
Publicado: (2018)

Simultaneous Extraction and Determination of Lignans from Schisandra chinensis (Turcz.) Baill. via Diol-Based Matrix Solid-Phase Dispersion with High-Performance Liquid Chromatography
por: Wang, Yinpeng, et al.
Publicado: (2023)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
por: Raunio, Hannu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g650ariimdg8v1o2eph8nrjjkb