Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

We reported previously that a 2′ fluoro-modified (2′ F) phosphorothioate (PS) antisense oligonucleotides (ASOs) with 5–10–5 gapmer configuration interacted with proteins from Drosophila behavior/human splicing (DBHS) family with higher affinity than PS-ASOs modified with 2′-O-(2-methoxyethyl) (2′ MO...

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Detalles Bibliográficos
Autores principales: Shen, Wen, De Hoyos, Cheryl L, Sun, Hong, Vickers, Timothy A, Liang, Xue-hai, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861398/
https://www.ncbi.nlm.nih.gov/pubmed/29390093
http://dx.doi.org/10.1093/nar/gky060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861398/
https://www.ncbi.nlm.nih.gov/pubmed/29390093
http://dx.doi.org/10.1093/nar/gky060

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