Single-particle trajectories reveal two-state diffusion-kinetics of hOGG1 proteins on DNA

We reanalyze trajectories of hOGG1 repair proteins diffusing on DNA. A previous analysis of these trajectories with the popular mean-squared-displacement approach revealed only simple diffusion. Here, a new optimal estimator of diffusion coefficients reveals two-state kinetics of the protein. A simp...

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Detalles Bibliográficos
Autores principales: Vestergaard, Christian L, Blainey, Paul C, Flyvbjerg, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861423/
https://www.ncbi.nlm.nih.gov/pubmed/29361033
http://dx.doi.org/10.1093/nar/gky004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861423/
https://www.ncbi.nlm.nih.gov/pubmed/29361033
http://dx.doi.org/10.1093/nar/gky004

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