Cargando…

Single-particle trajectories reveal two-state diffusion-kinetics of hOGG1 proteins on DNA

We reanalyze trajectories of hOGG1 repair proteins diffusing on DNA. A previous analysis of these trajectories with the popular mean-squared-displacement approach revealed only simple diffusion. Here, a new optimal estimator of diffusion coefficients reveals two-state kinetics of the protein. A simp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vestergaard, Christian L, Blainey, Paul C, Flyvbjerg, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861423/ https://www.ncbi.nlm.nih.gov/pubmed/29361033 http://dx.doi.org/10.1093/nar/gky004

Ejemplares similares

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway
por: Paquet, Nicolas, et al.
Publicado: (2015)

The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine
por: Šebera, Jakub, et al.
Publicado: (2017)

Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells
por: D’Augustin, Ostiane, et al.
Publicado: (2023)

Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability
por: Cilli, Piera, et al.
Publicado: (2016)

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
por: Visnes, Torkild, et al.
Publicado: (2020)

8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1
por: Kitsera, Nataliya, et al.
Publicado: (2011)

Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal
por: Lebraud, Emilie, et al.
Publicado: (2020)

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
por: Morin, José A., et al.
Publicado: (2015)

Molecular crowding enhances facilitated diffusion of two human DNA glycosylases
por: Cravens, Shannen L., et al.
Publicado: (2015)

Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase
por: Roberts, Victoria A., et al.
Publicado: (2012)

Thermodynamics of the multi-stage DNA lesion recognition and repair by formamidopyrimidine-DNA glycosylase using pyrrolocytosine fluorescence—stopped-flow pre-steady-state kinetics
por: Kuznetsov, Nikita A., et al.
Publicado: (2012)

The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging
por: Ying, Yilin, et al.
Publicado: (2022)

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo
por: Schuhwerk, Harald, et al.
Publicado: (2017)

Single-molecule FRET studies of the cooperative and non-cooperative binding kinetics of the bacteriophage T4 single-stranded DNA binding protein (gp32) to ssDNA lattices at replication fork junctions
por: Lee, Wonbae, et al.
Publicado: (2016)

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions
por: Weiser, Brian P, et al.
Publicado: (2018)

The histone variant H2A.Bbd is enriched at sites of DNA synthesis
por: Sansoni, Viola, et al.
Publicado: (2014)

FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response
por: Chen, Zhi-Wei, et al.
Publicado: (2014)

PCNA directs type 2 RNase H activity on DNA replication and repair substrates
por: Bubeck, Doryen, et al.
Publicado: (2011)

Excision of uracil from DNA by hSMUG1 includes strand incision and processing
por: Alexeeva, Marina, et al.
Publicado: (2019)

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1
por: Liu, Lili, et al.
Publicado: (2017)

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes
por: Grimme, Jill M., et al.
Publicado: (2010)

Kinetics of endogenous mouse FEN1 in base excision repair
por: Kleppa, Liv, et al.
Publicado: (2012)

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2
por: Malfatti, Matilde Clarissa, et al.
Publicado: (2017)

RNase H1 facilitates recombinase recruitment by degrading DNA–RNA hybrids during meiosis
por: Liu, Chao, et al.
Publicado: (2023)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation
por: Meek, Katheryn
Publicado: (2020)

The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae
por: Meas, Rithy, et al.
Publicado: (2015)

High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases
por: Schermerhorn, Kelly M., et al.
Publicado: (2016)

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage
por: Li, Yinglu, et al.
Publicado: (2018)

Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities
por: Dannenberg, Rachel L, et al.
Publicado: (2022)

RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts
por: Wang, Wenjie, et al.
Publicado: (2021)

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
por: Richard, Derek J., et al.
Publicado: (2011)

NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks
por: Vidi, Pierre-Alexandre, et al.
Publicado: (2014)

Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks
por: Zheng, Sihao, et al.
Publicado: (2018)

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein
por: Kaur, Parminder, et al.
Publicado: (2018)

The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis
por: Liu, Jinqiang, et al.
Publicado: (2021)

Synergistic modulation of cyclobutane pyrimidine dimer photoproduct formation and deamination at a T(m)CG site over a full helical DNA turn in a nucleosome core particle
por: Song, Qian, et al.
Publicado: (2014)

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
por: Jakob, Burkhard, et al.
Publicado: (2011)

RNase H2 roles in genome integrity revealed by unlinking its activities
por: Chon, Hyongi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4cifj30h9ku8q90atgffsligcf