Phosphorylation of an intrinsically disordered region of Ets1 shifts a multi-modal interaction ensemble to an auto-inhibitory state

Multi-modal interactions are frequently observed in intrinsically disordered regions (IDRs) of proteins upon binding to their partners. In many cases, post-translational modifications in IDRs are accompanied by coupled folding and binding. From both molecular simulations and biochemical experiments...

Descripción completa

Detalles Bibliográficos
Autores principales: Kasahara, Kota, Shiina, Masaaki, Higo, Junichi, Ogata, Kazuhiro, Nakamura, Haruki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861456/
https://www.ncbi.nlm.nih.gov/pubmed/29309620
http://dx.doi.org/10.1093/nar/gkx1297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861456/
https://www.ncbi.nlm.nih.gov/pubmed/29309620
http://dx.doi.org/10.1093/nar/gkx1297

Ejemplares similares