Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites

RAD51 recombinase assembles on single-stranded (ss)DNA substrates exposed by DNA end-resection to initiate homologous recombination (HR), a process fundamental to genome integrity. RAD51 assembly has been characterized using purified proteins, but its ultrastructural topography in the cell nucleus i...

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Detalles Bibliográficos
Autores principales: Haas, Kalina T, Lee, MiYoung, Esposito, Alessandro, Venkitaraman, Ashok R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861458/
https://www.ncbi.nlm.nih.gov/pubmed/29309696
http://dx.doi.org/10.1093/nar/gkx1303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861458/
https://www.ncbi.nlm.nih.gov/pubmed/29309696
http://dx.doi.org/10.1093/nar/gkx1303

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