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Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites
RAD51 recombinase assembles on single-stranded (ss)DNA substrates exposed by DNA end-resection to initiate homologous recombination (HR), a process fundamental to genome integrity. RAD51 assembly has been characterized using purified proteins, but its ultrastructural topography in the cell nucleus i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861458/ https://www.ncbi.nlm.nih.gov/pubmed/29309696 http://dx.doi.org/10.1093/nar/gkx1303 |