Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications of genetic KO versus MO-mediated KD of the mesoderm-specifying Brachyury paralogs in the frog Xe...

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Detalles Bibliográficos
Autores principales: Gentsch, George E., Spruce, Thomas, Monteiro, Rita S., Owens, Nick D.L., Martin, Stephen R., Smith, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861998/
https://www.ncbi.nlm.nih.gov/pubmed/29478923
http://dx.doi.org/10.1016/j.devcel.2018.01.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861998/
https://www.ncbi.nlm.nih.gov/pubmed/29478923
http://dx.doi.org/10.1016/j.devcel.2018.01.022

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