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Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers

Pancreatic cancer is one of the most lethal malignancies. Treatment with the first-line agent, gemcitabine, is often unsuccessful because it, like other traditional chemotherapeutic agents, is non-specific, resulting in off-target effects that necessitate administration of subcurative doses. Alterna...

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Detalles Bibliográficos
Autores principales: Kratschmer, Christina, Levy, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862029/
https://www.ncbi.nlm.nih.gov/pubmed/29499935
http://dx.doi.org/10.1016/j.omtn.2017.11.013