Phenytoin as a last‐resort treatment in SCN8A encephalopathy

SCN8A encodes Nav1.6, one of the main voltage‐gated sodium channel subunits in the brain, and SCN8A mutations lead to epileptic encephalopathy. Particular mutations render the mutant channel more susceptible to inhibition by phenytoin. Yet, the potentially severe side effects of phenytoin maintenanc...

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Detalles Bibliográficos
Autores principales: Braakman, Hilde M., Verhoeven, Judith S., Erasmus, Corrie E., Haaxma, Charlotte A., Willemsen, Marjolein H., Schelhaas, H. Jurgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Short Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862112/
https://www.ncbi.nlm.nih.gov/pubmed/29588963
http://dx.doi.org/10.1002/epi4.12059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862112/
https://www.ncbi.nlm.nih.gov/pubmed/29588963
http://dx.doi.org/10.1002/epi4.12059

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