Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparall...

Descripción completa

Detalles Bibliográficos
Autores principales: Kotkowiak, Weronika, Lisowiec-Wachnicka, Jolanta, Grynda, Jakub, Kierzek, Ryszard, Wengel, Jesper, Pasternak, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862132/
https://www.ncbi.nlm.nih.gov/pubmed/29499943
http://dx.doi.org/10.1016/j.omtn.2017.12.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862132/
https://www.ncbi.nlm.nih.gov/pubmed/29499943
http://dx.doi.org/10.1016/j.omtn.2017.12.013

Ejemplares similares