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Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparall...
Autores principales: | Kotkowiak, Weronika, Lisowiec-Wachnicka, Jolanta, Grynda, Jakub, Kierzek, Ryszard, Wengel, Jesper, Pasternak, Anna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862132/ https://www.ncbi.nlm.nih.gov/pubmed/29499943 http://dx.doi.org/10.1016/j.omtn.2017.12.013 |
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