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Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye
The eye primordium arises as a lateral outgrowth of the forebrain, with a transient fissure on the inferior side of the optic cup providing an entry point for developing blood vessels. Incomplete closure of the inferior ocular fissure results in coloboma, a disease characterized by gaps in the infer...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862500/ https://www.ncbi.nlm.nih.gov/pubmed/29522511 http://dx.doi.org/10.1371/journal.pgen.1007246 |