Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that g...

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Detalles Bibliográficos
Autores principales: Senchuk, Megan M., Dues, Dylan J., Schaar, Claire E., Johnson, Benjamin K., Madaj, Zachary B., Bowman, Megan J., Winn, Mary E., Van Raamsdonk, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862515/
https://www.ncbi.nlm.nih.gov/pubmed/29522556
http://dx.doi.org/10.1371/journal.pgen.1007268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862515/
https://www.ncbi.nlm.nih.gov/pubmed/29522556
http://dx.doi.org/10.1371/journal.pgen.1007268

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