A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. We conducted a...

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Detalles Bibliográficos
Autores principales: Mai, Nguyen TH, Dobbs, Nicholas, Phu, Nguyen Hoan, Colas, Romain A, Thao, Le TP, Thuong, Nguyen TT, Nghia, Ho DT, Hanh, Nguyen HH, Hang, Nguyen T, Heemskerk, A Dorothee, Day, Jeremy N, Ly, Lucy, Thu, Do DA, Merson, Laura, Kestelyn, Evelyne, Wolbers, Marcel, Geskus, Ronald, Summers, David, Chau, Nguyen VV, Dalli, Jesmond, Thwaites, Guy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862527/
https://www.ncbi.nlm.nih.gov/pubmed/29482717
http://dx.doi.org/10.7554/eLife.33478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862527/
https://www.ncbi.nlm.nih.gov/pubmed/29482717
http://dx.doi.org/10.7554/eLife.33478

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