Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer

3-Phosphoglycerate dehydrogenase (PHGDH) has recently been identified as an attractive target in cancer therapy as it links upregulated glycolytic flux to increased biomass production in cancer cells. PHGDH catalyses the first step in the serine synthesis pathway and thus diverts glycolytic flux int...

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Detalles Bibliográficos
Autores principales: Unterlass, Judith E., Baslé, Arnaud, Blackburn, Timothy J., Tucker, Julie, Cano, Céline, Noble, Martin E.M., Curtin, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862567/
https://www.ncbi.nlm.nih.gov/pubmed/29568346
http://dx.doi.org/10.18632/oncotarget.11487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862567/
https://www.ncbi.nlm.nih.gov/pubmed/29568346
http://dx.doi.org/10.18632/oncotarget.11487

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