CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells

The CDK8/19 kinase module comprises a subcomplex that interacts with the Mediator complex and regulates gene expression through phosphorylation of transcription factors and Mediator subunits. Mediator complex subunits have been increasingly implicated in cancer and other diseases. Although high expr...

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Detalles Bibliográficos
Autores principales: Nakamura, Akito, Nakata, Daisuke, Kakoi, Yuichi, Kunitomo, Mihoko, Murai, Saomi, Ebara, Shunsuke, Hata, Akito, Hara, Takahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862592/
https://www.ncbi.nlm.nih.gov/pubmed/29568371
http://dx.doi.org/10.18632/oncotarget.24414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862592/
https://www.ncbi.nlm.nih.gov/pubmed/29568371
http://dx.doi.org/10.18632/oncotarget.24414

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