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Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements

We provide evidence for a mechanism of DNA repair that requires nuclear myosin/actin-dependent contact between homologous chromosomes to prevent formation of chromosomal rearrangement in human cells. We recently showed that DNA double strand breaks (DSBs) induced by γ-rays or endonucleases cause ATM...

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Detalles Bibliográficos
Autores principales: Evdokimova, Viktoria N., Gandhi, Manoj, Nikitski, Alyaksandr V., Bakkenist, Christopher J., Nikiforov, Yuri E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862602/
https://www.ncbi.nlm.nih.gov/pubmed/29568381
http://dx.doi.org/10.18632/oncotarget.24434