QSAR study and rustic ligand-based virtual screening in a search for aminooxadiazole derivatives as PIM1 inhibitors

BACKGROUND: Quantitative structure–activity relationship (QSAR) was carried out to study a series of aminooxadiazoles as PIM1 inhibitors having pk(i) ranging from 5.59 to 9.62 (k(i) in nM). The present study was performed using Genetic Algorithm method of variable selection (GFA), multiple linear re...

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Detalles Bibliográficos
Autores principales: Aouidate, Adnane, Ghaleb, Adib, Ghamali, Mounir, Chtita, Samir, Ousaa, Abdellah, Choukrad, M’barek, Sbai, Abdelouahid, Bouachrine, Mohammed, Lakhlifi, Tahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862716/
https://www.ncbi.nlm.nih.gov/pubmed/29564572
http://dx.doi.org/10.1186/s13065-018-0401-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862716/
https://www.ncbi.nlm.nih.gov/pubmed/29564572
http://dx.doi.org/10.1186/s13065-018-0401-x

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