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QSAR study and rustic ligand-based virtual screening in a search for aminooxadiazole derivatives as PIM1 inhibitors
BACKGROUND: Quantitative structure–activity relationship (QSAR) was carried out to study a series of aminooxadiazoles as PIM1 inhibitors having pk(i) ranging from 5.59 to 9.62 (k(i) in nM). The present study was performed using Genetic Algorithm method of variable selection (GFA), multiple linear re...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862716/ https://www.ncbi.nlm.nih.gov/pubmed/29564572 http://dx.doi.org/10.1186/s13065-018-0401-x |