Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

Activity-based probes (ABPs) are widely used to monitor the activity of enzyme families in biological systems. Inferring enzyme activity from probe reactivity requires that the probe reacts with the enzyme at its active site; however, probe-labeling sites are rarely verified. Here we present an enha...

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Detalles Bibliográficos
Autores principales: Hewings, David S., Heideker, Johanna, Ma, Taylur P., AhYoung, Andrew P., El Oualid, Farid, Amore, Alessia, Costakes, Gregory T., Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F., Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862848/
https://www.ncbi.nlm.nih.gov/pubmed/29563501
http://dx.doi.org/10.1038/s41467-018-03511-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862848/
https://www.ncbi.nlm.nih.gov/pubmed/29563501
http://dx.doi.org/10.1038/s41467-018-03511-6

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