CISNE: An accurate description of dose-effect and synergism in combination therapies

The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances a...

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Autores principales: García-Fuente, Amador, Vázquez, Fernando, Viéitez, José M., García Alonso, Francisco J., Martín, José I., Ferrer, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862869/
https://www.ncbi.nlm.nih.gov/pubmed/29563526
http://dx.doi.org/10.1038/s41598-018-23321-6
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author García-Fuente, Amador
Vázquez, Fernando
Viéitez, José M.
García Alonso, Francisco J.
Martín, José I.
Ferrer, Jaime
author_facet García-Fuente, Amador
Vázquez, Fernando
Viéitez, José M.
García Alonso, Francisco J.
Martín, José I.
Ferrer, Jaime
author_sort García-Fuente, Amador
collection PubMed
description The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances and might lead to erroneous predictions of synergistic or antagonistic behaviour. We have identified the source of inaccuracies and fixed it thereby improving the accuracy of those methods. Here we explain the main features of our approach and demonstrate its higher accuracy as compared to the standard methods. Therefore, this new implementation might have a huge impact in the reliability of future research on new Combination Therapies.
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spelling pubmed-58628692018-03-27 CISNE: An accurate description of dose-effect and synergism in combination therapies García-Fuente, Amador Vázquez, Fernando Viéitez, José M. García Alonso, Francisco J. Martín, José I. Ferrer, Jaime Sci Rep Article The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances and might lead to erroneous predictions of synergistic or antagonistic behaviour. We have identified the source of inaccuracies and fixed it thereby improving the accuracy of those methods. Here we explain the main features of our approach and demonstrate its higher accuracy as compared to the standard methods. Therefore, this new implementation might have a huge impact in the reliability of future research on new Combination Therapies. Nature Publishing Group UK 2018-03-21 /pmc/articles/PMC5862869/ /pubmed/29563526 http://dx.doi.org/10.1038/s41598-018-23321-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
García-Fuente, Amador
Vázquez, Fernando
Viéitez, José M.
García Alonso, Francisco J.
Martín, José I.
Ferrer, Jaime
CISNE: An accurate description of dose-effect and synergism in combination therapies
title CISNE: An accurate description of dose-effect and synergism in combination therapies
title_full CISNE: An accurate description of dose-effect and synergism in combination therapies
title_fullStr CISNE: An accurate description of dose-effect and synergism in combination therapies
title_full_unstemmed CISNE: An accurate description of dose-effect and synergism in combination therapies
title_short CISNE: An accurate description of dose-effect and synergism in combination therapies
title_sort cisne: an accurate description of dose-effect and synergism in combination therapies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862869/
https://www.ncbi.nlm.nih.gov/pubmed/29563526
http://dx.doi.org/10.1038/s41598-018-23321-6
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